Jobs

Intern, Biochemistry

Posted on: January 14, 2021 Apply Now
Internship Expires May 1, 2021

Calico is seeking an intern to join the Biochemistry and Computing groups. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems. Working with the team for macromolecule structural biology studies, you will perform comprehensive protein structure analysis and structure-based biochemistry studies. At the same time, you will partner with our computational team on machine learning-based drug development. As such, the successful candidate will work closely with members of both the biochemistry technology lab and the machine learning team.

Responsibilities:

  • Work with protein-structure analysis software packages to design structure-based biochemical/biophysical assays
  • Perform assays for protein-protein interaction, protein-small molecule interaction, and enzymatic activity
  • Build machine learning models to predict assay results and to optimize experimental parameters

Position requirements:

  • Currently pursuing a PhD in computational science, biochemistry, structural biology or related field
  • Experience working with machine learning models for sequence data analysis such as those used for analyzing protein sequences and/or natural language processing
  • Experience with deep learning frameworks such as TensorFlow, Pytorch or Jax
  • Knowledge of protein science principles, including biochemical/biophysical properties of protein molecules
  • Experience with protein biochemistry assays
  • Experience with protein structure determination approaches such as cryoEM, SAXS, X-ray, or crystallography
  • Detail-oriented and organized
  • Strong teamwork and communication skills
  • Self-motivated with a “can-do” attitude
  • Flexible and able to respond quickly to shifting priorities
  • Available to work in South San Francisco throughout June, July and August of 2021 (due to the COVID-19 pandemic and its effect on Calico’s business needs and operations, you may be required to work from home and/or your anticipated start date may change or be delayed)

Nice to have:

  • Experience with molecular dynamics (MD) simulation methods
  • Experience of using active learning approaches to iteratively improve experimental performance
Apply Now