Pace Analytical Life Sciences, LLC is a premier Contract Research and Development Organization located just north of Cambridge, MA providing pharmaceutical development services for small molecules, protein biologics, oligonucleotide and mRNA therapeutics, and other biopharmaceutical drug candidates.
We seek a highly motivated scientist with experience in the biochemistry and molecular biology of nucleic acids to partner with our clients in their effort to discover and develop novel medicines such as viral gene therapies (e.g. AAV, Lentivirus), virus-like nanoparticles (VLP), lipid nanoparticles (LNP), or conjugates combining proteins and nucleic acids (e.g., mRNA, gRNA). Our clients include biotechnology and pharmaceutical companies from new startups to those with global operations working in the areas of cancer, vaccines, and rare genetic diseases. This individual will apply molecular expertise to develop methods and processes for the preparation, formulation, characterization, and testing of candidate therapeutics. Competitive applicants will be able to demonstrate an in-depth knowledge of techniques to manipulate and characterize nucleic acids, creative problem solving, an ability to collaborate in a cross-functional team, and clearly communicate scientific results. This is a full-time bench scientist position in Woburn, MA with title commensurate to experience.
• Independently design and execute experiments, analyze data, and understand the reliability of results.
• Present results and planned experiments clearly and concisely both verbally and in written documents.
• Maintain a strong awareness of scientific literature relevant to expertise and assigned projects.
• Mentor and train associate scientists.
• Write persuasive proposals to guide client pharmaceutical discovery and development.
• Continuously improve research and development skills and advance technical capabilities of Pace.
• Strive to meet agreed-upon timelines and regularly communicate progress to other stakeholders.
An Ideal Candidate will possess skills in the following areas:
• Develop and use methods to characterize nucleic acid therapeutics (e.g. mRNA, gRNA) including electrophoresis (agarose, PAGE, CE), chromatography (SEC, IEX, & IPRP HPLC/UPLC), spectroscopy (UV, CD), particulate analysis (e.g. DLS), and mass spectrometry (LC-MS, LC-MS/MS).
• Develop methods for the extraction and quantitation of nucleic acids from cells and complex biologic matrices (e.g. serum, plasma, tissue) using PCR (qPCR, RT-PCR).
• Knowledge of biochemistry and molecular biology techniques for the physical (e.g. annealing, hybridization, denaturation) and enzymatic (e.g. restriction, ligation, polymerization) manipulation of nucleic acids.
• Develop enzyme and cell-based assays for the characterization and determination of therapeutic nucleic acid activity. (e.g. mRNA, gRNA).
• Ability to learn new techniques and perform multiple tasks simultaneously.
Required Education and/or Experience:
• Ph.D. in biochemistry, molecular and cellular biology, or closely related discipline. Title will be commensurate with education and years of experience. M.S. candidates with 3+ years of industry experience and Ph.D. candidates with 0 – 2 years’ experience will be considered at the Associate Scientist III level. Scientist-level candidates to have at least 2 years of relevant industry or post-doctoral experience.
• Established track record of significant contributions as an individual technical expert as well as the ability to thrive in a multi-disciplinary team environment.
• Outstanding written and oral communication skills as well as polished presentation skills.
• Flexibility and outstanding time management skills.
The physical demands described herein are representative of those that must be met by an employee to successfully perform the essential functions of the job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Mobility to work in a lab and office setting, use standard office and lab equipment and stamina to sit for extended periods of time; exerting up to 20 pounds of force occasionally and/or up to 10 pounds of force frequently to lift, carry, push, pull or move objects; vision to read printed materials and computer screens; and hearing and speech to communicate in person or over the telephone.
Work is performed in a lab and office setting. Work is subject to chemicals, fumes, gasses, noxious odors and related items in a lab setting.
OFCCP Statement – Pace Analytical is an Equal Opportunity Employer and will not discriminate against any applicant for employment on the basis of race, age, religion, sex, veterans, individuals with disabilities, sexual orientation, or gender identity.
This position is full-time, permanent role working Monday through Friday 40 hours a week.